How does asbestos cause mesothelioma?

When asbestos fibers are inhaled into the air, they can reach the lungs. Fibers that remain in the lungs can travel to the ends of small airways and enter the pleural lining of the lung and chest wall.

How does asbestos cause mesothelioma?

When asbestos fibers are inhaled into the air, they can reach the lungs. Fibers that remain in the lungs can travel to the ends of small airways and enter the pleural lining of the lung and chest wall. These fibers can damage the cells of the pleura and, over time, cause mesothelioma. Mesothelioma is caused by exposure to asbestos.

When asbestos fibers are inhaled or ingested, they cause scarring and inflammation, which can develop into a mesothelioma tumor. Research has shown that 80% of all cases of mesothelioma are caused by known exposure to asbestos. There are no other proven causes of mesothelioma. Researchers continue to investigate other possible causes and risk factors, such as exposure to the SV40 virus or minerals that look like asbestos.

Mesothelioma was practically unknown until the 20th century. Mesothelioma incidence rates increased as industries expanded the use of. The only proven cause of mesothelioma is exposure to asbestos. Most risk factors for mesothelioma involve different sources of exposure to.

Other risk factors, such as the genes you inherit or exposure to the simian virus 40, known as SV40, have not been shown to cause mesothelioma. Other potential risk factors that remain unproven causes of mesothelioma include genetic factors and exposure to radiation, zeolite minerals, and the polio vaccine between 1955 and 1963 that was contaminated with simian virus 40 (SV40). Asbestos fibers take an average of 20 to 50 years to convert normal mesothelial cells into mesothelioma cancer cells. This time lag between exposure and the development of the disease is known as the latency period.

Asbestos fibers take decades to cause damage that leads to mesothelioma, but once mesothelial cells become cancerous, they can quickly form mesothelioma tumors that grow and spread within months to a few years. According to the American Cancer Society, 80% of mesothelioma cases are caused by known exposure to asbestos. Studies have shown that radiation treatment for other types of cancer or certain genetic markers may increase the risk of developing mesothelioma. However, asbestos is still the only proven cause of the disease.

If you are looking for support for mesothelioma, contact our patient advocates at (85) 404-4592.Asbestos was commonly used to build various types of structures in the 1930s and early 1980s due to its resistance to fire, water, sound, and more. Because of this, many industries used materials containing asbestos before the general public knew about the dangers of asbestos. Many people have been exposed to asbestos in some way from the 1930s to today. Although the use of asbestos fell sharply in the 1980s, after the mineral's hazards became widespread, it has not been completely banned.

Some of these workplaces still pose a risk of exposure to asbestos and mesothelioma even today. According to OSHA, 1.3 million workers have been exposed to asbestos today. The only known cause of mesothelioma is a history of exposure to asbestos. Many people were exposed to this mineral, as it was widely used from the 1930s to the early 1980s in buildings, building materials and hundreds of other products.

When asbestos breaks, such as during the extraction process or when removing asbestos insulation, dust can be created. If dust is inhaled or swallowed, asbestos fibers will settle in the lungs or stomach, where they can cause irritation that can lead to mesothelioma. It is not understood exactly how this happens. It may take 20 to 60 years or longer for mesothelioma to develop after exposure to asbestos.

We know that asbestos causes most cases of pleural mesothelioma. This starts in the two sheets of tissue that cover the lungs, called the pleura. Being exposed to large amounts of asbestos for a long period of time increases the risk of mesothelioma. Many people with mesothelioma in the abdomen (peritoneal mesothelioma) have also been exposed to asbestos.

Mesothelioma cancer occurs by inhaling or ingesting asbestos fibers. Asbestos fibers are lodged in the lining of the lungs, abdomen, or heart. Fibers cause inflammation and scarring. Exposure to asbestos can lead to the development of mesothelioma cancer.

These researchers addressed the paradox of how asbestos fibers that destroy cells could cause cancer, since a dead cell should not be able to grow or form a tumor. They found that when asbestos kills cells, it does so by inducing a process called programmed cell necrosis that leads to the release of a molecule called the high-mobility group box 1 protein (HMGB). HMGB1 initiates a particular type of inflammatory reaction that causes the release of mutagens and factors that promote tumor growth. Researchers found that patients exposed to asbestos have elevated levels of HMGB1 in their serum.

Therefore, they state that it may be possible to target HMGB1 to prevent or treat mesothelioma and to identify cohorts exposed to asbestos using simple serological tests of HMGB1. When asbestos fibers move to different parts of the body, they can cause different types of mesothelioma. Most people diagnosed with mesothelioma were exposed to asbestos while doing certain manual labor or serving in the military. Symptoms of mesothelioma may not appear until 30 to 50 years after initial exposure to asbestos.

Because the combination of cigarette smoking and exposure to asbestos greatly increases the risk of developing lung cancer, smoking is often confused as a risk factor for mesothelioma. People who are close to asbestos products and inhale or swallow asbestos fibers may develop mesothelioma decades later. Risk factors for developing mesothelioma are working around or indirectly around asbestos-related products, such as second-hand exposures seen with wives washing their loved ones' clothes and having asbestos dust. In Turkey, an asbestos-like mineral called erionite has been shown to increase the risk of mesothelioma.

Linda Molinari has more than 15 years of experience as a writer and advocate for patients with mesothelioma and the ban on asbestos. If you have symptoms of mesothelioma or any asbestos-related illness, it is important that you tell your doctor about your exposure to asbestos so that appropriate tests can be performed. Mesothelioma doctors will order CT scans and other tests based on your history of exposure to asbestos to determine if you are developing mesothelioma. Although rare, pericardial mesothelioma is caused by asbestos fibers that irritate the lining of the heart (pericardium), and testicular mesothelioma is caused by fibers that irritate the lining of the testicles (tunica vagina).

In the article, the researchers propose that by interfering with the inflammatory reaction caused by asbestos and HMGB1, it is possible to reduce the incidence of cancer among cohorts exposed to asbestos and decrease the rate of tumor growth among people already affected by mesothelioma. . .

Jeannie Kotzur
Jeannie Kotzur

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